维持性血液透析患者脑血管意外的危险因素及转归被引量：14

Risk Factors and Outcomes of Cerebrovascular Disorders in Maintenance Hemodialysis Patients

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摘要目的:了解维持性血液透析患者发生脑血管意外的相关危险因素及影响脑血管意外患者转归的主要因素。方法:回顾性分析17例脑血管意外的血液透析患者的临床资料。12例同期住院的维持性血液透析患者作为对照组。结果:脑血管意外组低密度脂蛋白(LDL)明显高于对照组(2.99±1.27mmol/L vs 2.01±0.52mmol/L,P<0.05)。两组在年龄、性别、透析龄、糖尿病病史、心血管疾病史、高血压及其控制情况、透析情况、血红蛋白、其它血脂指标、肾功能、钙磷乘积、ECG幅值等方面均无显著差异。脑出血组发病距末次透析时间短于脑梗死组,分别为17.7 h和60.0 h。脑出血组的病死率明显高于脑梗死组(88.9%和12.5%,P<0.01)。结论:LDL是尿毒症患者脑血管意外的可能危险因素,脑出血的病死率明显高于脑梗死组。 Objective: To investigate risk factors and outcomes of cerebrovascular disorders in maintenance hemodialysis patients anayze.Methods: We retrospectively analyzed 17 maintenance hemodialysis patients with cerebrovascular disorders and 12 maintenance hemodialysis patients served as control group. Results: Serum low-density lipoprotei (LDL) concentration in cerebrovascular disorders group was higher than that in control group significantly(2.99±1.27 mmol/L vs.2.01±0.52 mmol/L,p<0.05).But there was no significance difference in age,sex,dialysis age,diabetes,cardiovascular disease,hypertension and its control status,dialysis history,hemoglobin,serum lipid,BUN,Cr,UA,Ca×Pi and ECG voltage between two groups.The time between last dialysis and occurrence of cerebrovascular disorders was significantly shorter in cerebral hemorrhage group than that in cerebral infarction group(17.7 vs. 60.0 hours,P<0.01).The mortality in cerebral hemorrhage group was significantly higher than that in cerebral infarction group(88.9 vs. 12.5%,P<0.01).The uremic patients who died of cerebrovascular disorders survived 12.86±15.43 days after occurance.Conclusion:LDL was the possible risk factor of cerebrovascular disorders in maintenance hemodialysis patients. The mortality in cerebral hemorrhage group was significantly higher than that in cerebral infarction group.

作者章晓燕高键滕杰丁小强

机构地区复旦大学附属中山医院肾内科

出处《中国临床医学》北大核心 2005年第2期250-252,共3页 Chinese Journal of Clinical Medicine

关键词维持性血液透析患者脑血管意外危险因素及转归低密度脂蛋白回顾性分析 mol/L 尿毒症患者脑梗死脑出血临床资料控制情况血红蛋白血脂指标钙磷乘积透析时间对照组病死率糖尿病疾病史心血管高血压肾功能 Hemodialysis Cerebrovascular disorders Cerebral hemorrhage Cerebral infarction Low density lipoprotein(LDL)

分类号 R459.5 [医药卫生—治疗学] R743.3 [医药卫生—神经病学与精神病学]

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