摘要
目的探讨芪棱汤对大鼠脑缺血-再灌注损伤的保护作用。方法采用线栓加环扎法制备大鼠脑缺血-再灌注模型,将其分为空白对照组、假手术组、缺血再灌注组、芪棱汤组与补阳还五汤组。对大鼠进行神经学评分,并测定脑梗死边缘区Ca2+浓度。结果缺血3h时各组神经学评分及细胞Ca2+相近,缺血12h之后各个时点两用药组神经学评分及Ca2+浓度均低于缺血再灌注组,芪棱汤组数据又低于补阳还五汤组。结论芪棱汤对大鼠局灶性脑缺血-再灌注损伤有保护作用。
Objective:To study the protective effect of Qileng Decoctionon rats with cerebral is-chemia reperfusion injury.Methods:Middle cerebral aretery o cclusion r eperfusion(MCAO /IR)model in rat was made by thread emboli ging an d fastening method.Neurogra phy grade were e-valuated,and the concentration o f c ytoplasmic free calcium was measura ted in ischemic penumbra(IP).Results :There was statistic significance both in the evaluation of enurography g rade and the concentration of cytoplasmic feee c alcium in IP among ischemia reperfus ion group,group of QiLengDecoction and group of Buyanghuanwu Decoction at 12h,24h,48h,72h and 7d.Conclusion:Qileng Decoction can pr otect the brain cerebral ischemia reperfusion injury.
出处
《中国中医急症》
2005年第5期458-459,i001,共3页
Journal of Emergency in Traditional Chinese Medicine
基金
广东省中医药局资助课题(No.103124)
