摘要
本文对克拉玛依地区查见的２８例病期为１—４８个月的皮肤利什曼病人的皮肤损害进行了临床表现与病理变化的观察。皮肤的表现一般可分为丘疹或斑块、软性结节或脓肿、溃疡及硬性结节４种临床类型。相应的组织病变，在丘疹或斑块型，主要为原虫引起的巨噬细胞聚集及炎性反应，软性结节或脓肿及溃疡型则为原虫大量繁殖导致的组织坏死液化及脱落，硬性结节主要是受损组织的修复与增生及原虫数的大量减少。以上结果，对了解皮肤利什曼病的病理演变过程以及与皮肤型黑热病的鉴别诊断均有一定帮助。
Clinicopathological observations on 28 cases of cutaneous leishmaniasis with dermal lesions for 1 48 months were carried out. The cutaneous lesions detected in the patients might be categorized into four types.1. Papular eruption or plaque. It was predominated by inflammatory reaction,including numerous leishmanias and macrophages and other inflammatory cells infiltrating in cutaneous tissue.2. Soft node or abscess.It was composed of necrotic tissues,many degenerated and dead leishmanias as well as disintegrated inflammatory cells in the focal site.3. Ulceration.It contained necrotic cutaneous tissue,a considerable number of dead leishmanias and granuloma formation.4. Hard nodule.Tissue proliferation and healing were distinct,which was indicated by the increase of fibrobcasts and fibrous tissue formation,round cells infiltration as well as the foreign body giant cell appearance;besides,a few leishmanias existed;occasionally,scar formation was visible in the superficial and deep layers of the derma. The paper presented for the first time in the histopathological changes of cutaneous leishmaniasis in China.And,the description of cutaneous lesions will be of significance in the differential diagnosis between cutaneous leishmaniasis and post kala azar dermal leishmaniasis.
出处
《中国寄生虫学与寄生虫病杂志》
CAS
CSCD
北大核心
1994年第3期182-184,共3页
Chinese Journal of Parasitology and Parasitic Diseases
基金
国家自然科学基金
关键词
克拉玛依
皮肤
利什曼病
病理学
Karamay,cutaneous leishmaniasis,clinicopathological study,lesion classification
