摘要
背景:血小板参数变化可以反映人体凝血功能,但是关于血小板参数在血栓性疾病患者中变化的研究,没有一致的说法,还存在争论。目的:观察脑梗死患者血小板参数变化的规律,探讨使用血细胞分析仪观察患者血小板参数变化是否可行。设计:以患者和健康人对研究对象,病例-对照的验证性研究。单位:一所大学的检验科和内科。对象:2002-01/03华中科技大学同济医学院附属协和医院神经内科确诊的初次发病的脑梗死患者37例,其中男28例,女9例;年龄45～87岁。对照组为37例健康体检者,其中男20例,女17例;年龄40～60岁。方法:用血细胞分析仪检测37例脑梗死患者的血小板分布宽度、血小板平均容积、大血小板比率、血小板数量的变化,同时以健康体检者作对照。主要观察指标:两组对象的血小板各参数变化。结果:血小板分布宽度与大血小板比率、大血小板比率与血小板平均容积之间为正相关关系(r=0.99,0.92,P<0.001),血小板数量与血小板平均容积、大血小板比率之间为负相关(r=-0.58,-0.59,P<0.05)。脑梗死患者的血小板分布宽度、血小板平均容积、大血小板比率犤(14.51±2.88)%,(10.95±1.48)fl,(34.24±11.23)%犦均高于健康体检者犤(12.86±2.02)%,(10.19±1.29)fl,(28.47±9.41)%犦,差异有显著性意义(P分别为0.01931,0.02177,0.
BACKGROUND:The parameters of blood platelet(B PLT) can reflect its thrombo function,but the variation of blood platelet parameters in patients with thrombotic disease is controversial and not unanimous. OBJECTIVE:To observe the changing rule of the B PLT parameters in patients with cerebral infarction(CI),and investigate whether blood cell counter can be used in the evaluation of the variation of B PLT parameters in CI patients. DESIGN:A case control and experimental study based on patients and healthy people. SETTING:Department of laboratory and internal medicine in a university. PARTICIPANTS:During the January and March 2002,37 CI patients including 28 males and 9 females aged 45-87 years were selected from Department of Neurology,Union Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology.Among 37 healthy people,20 males and 17 females aged 40-60 years were selected as control group. METHODS:Platelet distribution width(PDW),mean platelet volume (MPV),platelet large cell ratio(P LCR) and the changing quantity of B PLT of 37 CI patients were analyzed with blood cell counter,meanwhile,the healthy people were analyzed as control subjects. MAIN OUTCOME MEASURES:Changes of B PLT parameters in two groups respectively. RESULTS:A positive relation between PDW and P LCR was observed and between P LCR and MPV as well(r=0.99,0.92,P< 0.001).A negative correlation between B PLT quantity and MPV was observed and also between B PLT quantity and P LCR(r=-0.58,-0.59,P< 0.05).In CI patients,PDW,MPV and P LCR were(14.51±2.88)%,(10.95±1.48) fl and(34.24±11.23)%respectively,which were higher than those of healthy people[(12.86±2.02)%,(10.19±1.29) fl,(28.47±9.41)%] respectively,and the difference was significant(P=0.019 31, 0.021 77 and 0.026 35),but there was no significant difference between the two groups in B PLT quantity. CONCLUSION:The blood platelets' parameters in CI patients, which reflect the function of the B PLT,are significantly higher than those in healthy people.It shows that the enhanced function of platelet is a risk factor of cerebral infarction,the use of blood cell counter in analysis can observe the variation of the platelets' function rapidly and accurately.It can be a useful method of the therapy and prevention in CI patients.
出处
《中国临床康复》
CSCD
北大核心
2005年第13期222-223,共2页
Chinese Journal of Clinical Rehabilitation
