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肿瘤治疗靶点survivin及其分子拮抗剂的研究进展 被引量：3

Recent advances in research on survivin and its moecular antagonists
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摘要 survivin是IAP家族成员之一,分布于有丝分裂元件,具有调控细胞有丝分裂和抑制细胞凋亡的功能。survivin在大多数正常组织中未被检测,但在肿瘤组织中过量表达。survivin作为癌症治疗的一个重要靶点,针对survivin的多种分子拮抗剂的研究已经取得了一定成果。 Survivin is a member of the IAP family, which has been shown to localize to various components of the mitotic apparatus. Survivin is not only an apoptosis inhibitor, but a mitotic regulator as well. Survivin is Absolutely undetectable in normal tissues, but over-expressed in all the most common human cancers. Survivin is considered as an important target in cancer treatment, and the research on its molecular antagonists has gained encouraging achievements.
作者 黄玮琳 周向军 王永祥
机构地区 上海交通大学药学院
出处 《中国药理学通报》 CAS CSCD 北大核心 2005年第4期389-392,共4页 Chinese Pharmacological Bulletin
基金 上海市科委重大科技攻关项目资助课题(No04DZ19211)
关键词 SURVIVIN 肿瘤 靶点 分子拮抗剂 survivin cancer target molecular antagonist
分类号 R-05 [医药卫生] R329.28 [医药卫生—人体解剖和组织胚胎学]
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参考文献25

  • 1潘金飞,彭淑牖.凋亡抑制因子Survivin与肿瘤关系研究进展(文献综述)[J].国外医学（外科学分册）,2003,30(3):131-133. 被引量：4
  • 2Altieri DC. Validating survivin as a cancer therapeutic target[J]. Nat Rev Cancer, 2003,3(1):46-54.
  • 3Verdecia MA, Huang H, Dutil E et al. Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement[J]. Nat Struct Biol, 2000,7(7):602-8.
  • 4Li F, Ackermann EJ, Bennett CF et al. Pleiotropic cell-division defects and apoptosis induced by interference with survivin function[J]. Nat Cell Biol, 1999,1(8):461-6.
  • 5Skoufias DA, Mollinari C, Lacroix FB et al.Human survivin is a kinetochore-associated passenger protein[J]. J Cell Biol,2000,151(7):1575-82.
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  • 7Li F, Altieri DC. Transcriptional analysis of human survivin gene expression[J]. Biochem J, 1999,344(2):305-11.
  • 8Zhao J, Tenev T, Martins LM et al. The ubiquitin-proteasome pathway regulates survivin degradation in a cell cycle-dependent manner[J]. J Cell Sci,2000,113(23):4363-71.
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二级参考文献38

  • 1[2]Ambrosini G, Adida C, Altieri DC. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med, 1997; 3(8):917～21
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  • 9[10]Grossman D, Kim PJ, Schechner JS, Altieri DC. Inhibition of melanoma tumor growth in vivo by survivin targeting. Proc Natl Acad Sci USA, 2001;98(2):635～40
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中国药理学通报
2005年 第4期

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