摘要
目的 研究白花蛇舌草总黄酮(FOD)的免疫调节作用。方法 通过测定小鼠脾细胞IgM抗体形成,脾淋巴细胞的增殖反应,小鼠血清IL- 2和IFN -γ含量以及观察对小鼠白细胞数量的影响,研究白花蛇舌草总黄酮的免疫调节作用。结果 白花蛇舌草总黄酮(15、30、60mg·kg-1 )促进免疫功能低下小鼠由ConA或LPS诱导的脾淋巴细胞的增殖反应,并提高小鼠血清IL 2和IFN -γ的含量;白花蛇舌草总黄酮(60mg·kg-1 )促进免疫功能低下小鼠脾脏IgM抗体形成,并升高抗肿瘤药物(环磷酰胺或阿糖胞苷)所致的小鼠白细胞减少。结论 白花蛇舌草总黄酮具有增强机体特异性免疫功能和非特异性免疫功能的作用。
Aim To investigate the immunomdulatory effects of total flavones of oldenlandia diffusa willd (FOD).Methods In immunosuppressed mice induced by cyclophosphamide, IgM production,proliferation of T and B lymphocytes, levels of IL-2 and INF-γ in serum were used to study the specific immunity of FOD. White blood cell count of mice suppressed by cyclophosphamide and cytarabine was used to observe the non-specific immunity of FOD.Results FOD(60 (mg·kg^(-1))) enhanced IgM production in (immunosup-)pressed mice induced by Cy and white blood cell count of mice suppressed by cytarabine and cyclophosphamide ;FOD(15,30 and 60 mg·kg^(-1)) increased proliferation of T and B lymphocytes and enhanced levels of IL-2 and INF-γ in serum in immunosuppressed mice induced by cyclophosphamide. Conclusion FOD enhances the specific and non-specific immunity.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2005年第4期444-447,共4页
Chinese Pharmacological Bulletin
基金
安徽省科学技术厅引导型资助项目(No04023055)
