摘要
目的:观察中医实热证、虚热证两种不同证型之间与外周血 T 淋巴细胞亚群的变化差异。方法:采用间接免疫荧光法检测正常对照组30例、实热证患者27例、虚热证患者35例 T 细胞亚群的变化。结果:实热证、虚热证组患者与正常对照组相比,T 细胞亚群 CD_3、CD_4、CD_4/CD_8水平显著下降(P<0.05或 P<0.01),其中虚热证组 CD_4下降明显(P<0.05);而 CD_8水平升高只在实热证组患者有显著差异(P<0.01)。结论:虚热证、实热证两组患者都存在 T 细胞免疫功能紊乱。虚热证细胞免疫功能低下,而实热证虽然 T 淋巴细胞亚群亦低于正常人,但高于虚热证组。T 淋巴细胞亚群变化可为实热证、虚热证的客观化研究提供依据。
Objective:To observe differences of peripheral T-lymphocyte subsets between the patients of excess-heat syndrome and deficiency-heat syndrome.Methods:T-lymphocyte subsets in a normal group(n=30),excess-heat syndrome group(n=27)and deficiency-heat syndrome group(n=35)were detected with indirect immunofluorescence staining method.Results:CD_3,CD_4 and CD_4/CD_8 ratio decreased significantly in the excess-heat syndrome group arid the deficiency-heat syndrome group as compared with normal group(P<0.05 or P<0.01).CD_4 in the deficiency-heat syndrome group decreased significantly(P<0.05)and CD_8 in the excess-heat syndrome group increased significantly(P<0.01).Conclusion:The patients of deficiency-heat syndrome and excess-heat syndrome have dysfunction of T-lymphocytes,being lower than normal persons,but in the patients of excess-heat syndrome they are higher than those of the deficiency-heat syndrome.It provides basis for study on objectiveness of excess-heat syndrome and deficiency-heat syndrome.
出处
《中医杂志》
CSCD
北大核心
2005年第4期289-290,共2页
Journal of Traditional Chinese Medicine
基金
广东省中医药管理局科研资助项目(97262)
