摘要
目的:检测毛细支气管炎的止凝血分子标志物及分析其临床意义。方法:测定毛细支气管炎患儿治疗前后的D-二聚体(D-Dimer)、活化部分凝血酶时间(APTT)及抗凝血酶Ⅲ(AT-Ⅲ),并进行对比。结果:67.8%毛细支气管炎患儿的D-Dimer升高,患儿对照组治疗前31例患儿的APTT明显缩短,AT-Ⅲ活性明显降低。患儿治疗组治疗后30例患儿的D-Dimer明显下降、APTT明显延长、AT-Ⅲ活性明显增高。结论:毛细支气管炎存在高凝状态,其分子标志物为D-Dimer升高、APTT缩短及AT-Ⅲ降低,经肝素治疗后它们的改善可用来评价肝素的抗凝效果。
Objective:To test molecular markers of coagulation of bronchiolitis and analyse its clinical significance.Methods:D-Dimer, activated partial thrombin time (APTT) and anti-thrombin Ⅲ (AT-Ⅲ) levels were measured and compared in bronchiolitis before and after treatment with heparin.Results:D-Dimer level was increased in 67.8% of children with bronchiolitis. APTT significantly shortened, and AT-Ⅲ activity remarkably reduced in 31 children of control group before treatment.D-Dimer significantly reduced, APTT significantly increased, and AT-Ⅲ activity remarkably increased in 30 children of control group after treatment.Conclusion:There existed hypercoagulability state in bronchiolitis, its molecular markers were the higher level of D-Dimer, the shortened APTT and the lowered activity of AT-Ⅲ, which could be improved after treatment with heparin to evaluate the anticoagulation effect of heparin.
出处
《中国妇幼保健》
CAS
北大核心
2005年第9期1086-1087,共2页
Maternal and Child Health Care of China
关键词
毛细支气管炎
高凝状态
肝素
Bronchiolitis
Hypercoagulability state
Heparin
