摘要
用ＥＬＩＳＡ方法检测结核性和非结核性（癌性及漏出液）胸水及血清中的可溶性白细胞介素２受体（ｓＩＬ－２Ｒ）。结果显示：结核组ｓＩＬ－２Ｒ水平明显增高（２４６４±１００１Ｕ／ｍｌ），与癌性胸腹水组（７５２±４１８Ｕ／ｍｌ）及漏出液组（４１０±３１５Ｕ／ｍｌ）比较有显著性差异（Ｐ＜０．００１）。与胸水中腺苷脱氨酶活性（ＡＤＡ）呈正相关（ｒ＝０．６８８，Ｐ＜０．００１）。敏感性及特异性均为９０％以上。提示用本法检测胸腹水的ｓＩＬ－２Ｒ对于结核性胸腹水的诊断及鉴别诊断有重要意义。
he levels of soluble IL-2R were determined in pleural
fluid and serum from 30 patientswith tuberculous pleurisy and 57
nontuberculous(30 cases of malignant,27 cases of transudative,There
were significantly elevated soluble IL-2R values in tuberculous
pleural fluid(2464±1001U/ml)as compared with pleuroperitoneal fluid
of nontuberculous etiology including malig-nant(752± 418U/ml)and
transudative(4l0± 315U/ml)effusions.In patients with tubercu-lous
pleurisy,the level of soluble IL-2R in pleural fluid was markedly
greater than that inserum.A significant positive correlation was
observed between soluble IL-2R levels and adeno-sine deaminase levels
in tuberculous pleural fluid.Fixing the cut off points of soluble
IL-2R val-ues at 1500U or l000U the tuberculous pleural effusion
cases were differentiated from the non-tuberculous with a
sensitivity、specificity、postive predictive value、negative
predictive value andaccuracy of over 90 percent.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1994年第3期182-185,共4页
Chinese Journal of Immunology
关键词
胸腔积液
白细胞介素2
结核性
SIL-2R
Adenosine deaminase Tuberculousis pleural effusion
