摘要
目的分析儿童急性播散性脑脊髓炎的临床和实验室特点。方法对1999年4月～2003年12月间住院的16例急性播散性脑脊髓炎患儿的临床表现、实验室检查及预后进行回顾性分析。结果15例有前驱病史(93.75%)。7例为脑脊髓型,8例脑型,1例脊髓型。10例脑脊液常规、生化异常,10例IgG指数增高(66.67%),7例脑脊液寡克隆带(OB)阳性(46.67%)。11/15例MRI异常(73.33%),多灶性(72.72%);1例CT异常。15/16例脑电图异常(93.75%)。所有病例均予激素治疗,疗效显著。结论急性播散性脑脊髓炎是中枢神经系统常见的炎性脱髓鞘病变,神经系统临床表现多样,脑脊液、MRI检查有助于诊断,激素治疗有效,预后良好。
Objective To study the clinical and laboratory characteristics of acute disseminated en-cephalomyelitis(ADEM)in children.Methods All clinical data including clinical manifestations,laboratory results and prognosis were analyzed retrospectively in16children with ADEM.Results There were15cases with prodrome(93.75%).8cases were presented as encephalitis,7cases as encephalomyelitis and1case as myelitis.Results of CSF routine examination were abnormal in10cases.IgG index was increased in10cases(66.67%)and oligoconal bands in CSF were positive in7cases(46.67%).There were11of15cases(73.33%)with abnormal MRI and1case with abnormal CT scans.EEG was abnormal in15of16cases(93.75%).All patients were treated with corticosteriod with a good recovery.Conclusions ADEM was an inflammatory demyelinating disease of the CNS with multiple neurological signs,CSF and MRI examinations were helpful to establish the diagnosis,corticosteroid treatment was effective,its prognosis was good.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2005年第5期280-281,290,共3页
Journal of Clinical Pediatrics
关键词
急性播散性脑脊髓炎
儿童
临床
acute disseminated encephalomyelitis children clinical
