摘要
在18只麻醉大鼠上刺激蓝斑可以抑制强电流刺激后肢引起的后二头半腱肌的屈反射和16个背角神经元的C反应,在脊髓腰3—4节段表面滴注Yoh(0.2％,5—10μl)明显减弱蓝斑对反射的抑制而不影响其对C反应(n=10)的抑制。结果提示,α_2受体参与蓝斑对伤害性反射的抑制,而蓝斑对背角神元C反应的抑制可能由其它递质介导。
The effect of a2-adrenoceptor antagonist yohimbine ( Yoh ) on locus coeruleus (LC)-induced spinal antinociception was investigated in 18 anesthetized Wistar rats. Stimulation of LC markedly inhibited both nociceptive reflex of the posterior biceps semitendinosus (PBST) muscle and C responses of 16 wide-dynamic range (WDR) neurons of the dorsal horn. Application of Yoh (0.2 %, 5-10 μl) to the surface of spinal cord at L3-4 attenuated the LC-induced inhibition of nociceptive reflex without affecting that of C responses of 10 WDR neurons that were tested in 6 rats. The results suggested that LC may exert its inhibitory action on the nociceptive reflex via a2 adrenoceptors somewhere other than the WDR neurons in the spinal dorsal horn.
出处
《中国药理学报》
CSCD
1994年第6期491-494,共4页
Acta Pharmacologica Sinica
关键词
肾上腺素受体
痛测定
蓝斑
脊髓
育亨宾
adrenergic receptors
pain measurement
electromyography
locus coeruleus
norepinephrine
spinal cord
yohimbine
