摘要
用混合溶剂将米托蒽醌聚氰基丙烯田正丁酯毫微球溶解后，采用分光光度法测定其中的米托蒽醌的含量。测定波长为６６０ｎｍ，测定线性范围为０．３～２．０ｍｇ／１００ｍｌ，回收率为９９．６１％，ＲＳＤ为０．５９％（ｎ＝３）。方法准确可靠，简便快速，可供该类毫微球剂或微球剂中药物含量测定参考。
We determined the contents of mitoxantrone in polybutylcyanoacrylate nanospheresby spectrophotometry after dissolving the mitoxantrone-polybutylcyanoacrylate nanosperes in asolvent mixture. The determining wavelength was 660nm, the linear range 0.3～2. 0mg/100ml,the average recovery of mitoxantrone in polybutylcyanoacrylate nanosperes 99. 61%, the relativestandard deviation 0.59%(n=3),and the correlation coefficient of mitoxantrone 0.9999.Themethod is accurate and simple,and can be used as a reference for other nanospheres preparations.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1994年第7期422-424,共3页
Chinese Pharmaceutical Journal
基金
国家自然科学基金
关键词
米托蒽醌
毫微球
分光光度法
mitoxantrone, polybutylcyanoacrylate nanospheres,spectrophotometry
