摘要
采用随机公开交叉试验比较沙丁胺醇控释片（Ｖｏｌｍａｘ）和茶碱缓释片（Ｔｈｅｅｄｕｒ）对２９例支气管哮喘患者的作用及副作用。结果：Ｖｏｆｍａｘ及Ｔｈｅｅｄｕｒ均能显著改善，哮喘患者的肺通气功能（ＦＶＣ，ＦＥＶ１，ＰＥＦ），降低２４ｈＰＥＦＲ，两组比较无显著差异（Ｐ＞０．０５）。治疗期间二组之晨、夜ＰＥＦＲ，症状计分，无症状天数及气雾剂用量亦无显著差异。而Ｖｏｌｍａｘ的副反应远较Ｔｈｅｅｄｕｒ少而轻，且无需测定血药浓度，更易被患者接受，因此临床治疗中沙丁胺醇控释片更具优越性。
he efficacy and side effects of salbutamol controlled release tablet(SCR. Volmax 8 mg、bid X 14 days)was comparedwith slow release theophylline tablet(SRT,Theodur 0.2～0.3g,bid × 14days)in an open, ramdomized, crossover study of29 bronchial asthmatics(17～64 yrs).The dose of SRT for each patients was titrated such that the plasma concentrationswere in the range 10～2Omg/L,The results showed that FEV1 ,FVC ,PEF increased significantly, and 24 hours PEF vari-able rate decreased significantly in both SCR group and SRT group after treatment ( all P<0.05).There were no significantlydifference between SCR group and SRT group in FEV1 .FVC ,and PEF before and after treatment( all P>0.05).And no sig-nificantlv difference found between these two groups in diurnal PEFR、symptom scores,symptorn-free davs and additional in-haled bronchodilator usage during treatment period ( all P> 0.05).Side effects were much less and slight in SCR group com-pared With SRT group. SCR is easier to be recepted by the patiens,and need not to be titrated Of plasma concentration. SCRhas more benifits in clinical treatment.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1994年第4期158-160,共3页
Chinese Journal of Hospital Pharmacy
关键词
沙丁胺醇
控释片
茶碱
哮喘
salbutamol controlled release tablet ,slow release theophylline tablet ,bronchial asthma
