摘要
６头装有暂时性颈静脉血管瘘的黑白花品种新生犊牛，在从出生至１５日龄的围产期内每天测定血浆葡萄糖（Ｇ）、胰岛素（Ｉｎｓ）和胰高血糖素（Ｇｃ）的基本浓度，可见１日龄喂初乳前Ｇ、Ｉｎｓ和Ｇｃ的浓度分别是１１９６．０±１５２．２ｍｇ／Ｌ、（７．３３±１．４３）×１Ｏ３Ｕ／Ｌ和６８５．３９±９５．４２ｎｇ／Ｌ。Ｇ于第２天明显下降，第３天回升，以后相对稳定；Ｉｎｓ第２天升高，以后下降，５日龄后相对稳定；Ｇｃ４日龄内逐日下降，５日龄后达到相对稳定水平。第１天喂初乳引起Ｉｎｓ显著升高，Ｇｃ下降，Ｇ无变化或者降低；以后喂初乳或常乳均引起Ｉｎｓ和Ｇ一致性升高，进食引起的Ｉｎｓ释放反应随日龄增长明显增加，Ｇｃ下降。不同日龄时灌注精氨酸均引起Ｉｎｓ显著增加，Ｇｃ早期无显著变化，７日龄后显著增加，同时Ｇ并无明显变化。灌注Ｇ引起Ｇ和Ｉｎｓ两者都增加，Ｇｃ下降。随日龄增长胰岛Ｂ细胞对精氨酸和Ｇ的反应明显加强。
Six spontaneously delivered
Holstein male calves with 40─50 kg birth weight were chosenfor the experiments and
catheterized into jugular vein within 1 2 hours after birth.The resultsshowed that the plasma
concentrations of insulin(Ins),glucagon(Gc)and glucose(G)before ini-tial colostrum feeding on the
lst day were(7.33±1.43)× 10-3U/L,685.39±95.42 ng/L and11 96,0±152.2 mg/L respectively.
G decreased obviously on the 2nd day followed bv a little in-crease on the 3rd day and then
tended to remain at a stable level. Ins increased on the 2nd day,then decreased on the next two
days and remained stable after about 5 days of age. Gc decreasedday by day within 4 days of
age followed by remaining stable. The response of Ins to feeding wasgradual increase with
increasing age during perinatal period. Gc decreased before 7 days of agefollowed by short
increase and then obvious decrease on 14th day of age.Infusion of L-arginine( 10%, 50ml /
5min,i.v)increased Ins release, but did not change G and Gc.Infusion ofexogenousG(50%, 50ml/
ml,i.v)caused increase in both Ins and G and decrease in Gc.It isconcluded that the pancreatic
endocrine function has basically matured at birth,but continue todevelop and mature during
perinatal period in newborn calves.
出处
《中国应用生理学杂志》
CAS
CSCD
1994年第2期173-175,共3页
Chinese Journal of Applied Physiology
关键词
新生犊牛
胰腺
内分泌机能
newborn calf
perinatal
period
insulin
glucagon
blood glucose
development
