摘要
采用肠系膜上动脉夹闭法造成休克模型，观察救脱Ⅱ号注射液的药效学。结果提示本品能迅速升高肠系膜上动脉夹闭型休克家兔的血压，降低死亡率；并能明显降低休克家兔心、肝、肾的脂质过氧化物含量；减轻休克家兔心、肝、肾组织线粒体、溶酶体损伤，保护重要脏器细胞超微结构。说明救脱Ⅱ号注射液对肠系膜上动脉夹闭型休克家兔有较好的治疗作用，初步阐明药物的作用机理。
Tang's SMAO method was adopted to produce shock model to observe the efficacy of the Jiutuo II(JTII)intravenously given. It was found that JTII could normalize the BP rapidly, which were superior to that of Dopamine and NS groups (P<0.05, P< 0.0l). At the same time, it could decrease mortality rate, comparing with Dopamine and NS the difference was significant (P<0.05, P< 0.01);and it could also inhibit the formation of lipid peroxides(LPO). The contents of LPO in heart, liver,kidney of shock rabbit were obviously lower than that of Dopamine and NS groups (P<0.05, P <0.01). The electron microscopy indicated that the drug could relieve the injury of mitochondria and lysosome in the tissues of heart, liver and kidney and protect the cellular ultrastructure of cardinal viscera. This study suggests that the JTII had good efficacy in treating the shock rabbit caused by SMAO method.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1994年第10期604-606,共3页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
救脱II号
注射液
休克
线粒体
Jiutuo Ⅱ injection, shock, lipid peroxides, mitochondria, lysosome
