摘要
用犬心脏停跳再复跳模型，观察低温对缺血再灌流心肺脂质过氧化和乳酸脱氢酶的影响。结果显示，再灌期低温３４～３６℃组和３０～３２℃组心肌丙二醛（ＭＤＡ）含量明显增加，低温３０～３２℃组乳酸脱氢酶（ＬＤＨ）明显降低（Ｐ＜０．０５）。肺组织ＭＤＡ、ＬＤＨ变化不明显（Ｐ＞０．０５）。表明低温下心肌脂质过氧化损伤仍然明显。低温对肺再灌流损伤有一定的保护作用。
Effects of hypothermia on lipid peroxides and lactic dehydrogenase (LDH ) in canine heart and lung tissue following cardiac arrest and resuscitation were studied. Twenty-one healthy dogs were randomly divided into four groups: non-ischemic control (n = 4 ); ischemic control (n= 4) ; 34- 36℃ (n= 6 ); 30-32℃ hypothermia (n = 7 ). The malondiadehyde (MDA) content of the heart tissue in groups of 34- 36℃ and 30 - 32 ℃ increased significantly, and the content of LDH in 30 - 32 ℃ hypothermia group decreased significantly (p <0. 05). The contents of MDA and LDH in lung tissue did not change significantly. The results showed that hypothermia 30～36℃could not influence the reaction of lipid peroxi- datlon in heart tissue,but could restrict the re-action in lung tissue.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
1994年第1期20-22,共3页
Chinese Journal of Anesthesiology
