摘要
对国产氟康唑作体内外药效学研究中发现不论在体外或体内均具有较好的广谱抗真菌作用。体外对３１株白念珠菌（白念ＭＩＣ为０．８～２００ｍｇ／Ｌ）、２４株新型隐球菌（新隐ＭＩＣ为２．２４～３５．４ｍｇ／Ｌ）及部份皮癣菌等均有较好的抑菌作用，其ＭＩＣ范围及ＭＩＣ５０、ＭＩＣ９０的结果均与国外同类制品（０．２～＞１００ｍｇ／Ｌ及３．１３～１２．５ｍｇ／Ｌ）相似，且对国外尚未报道的马尔尼菲青霉菌均有一定抑菌作用。体内对白念与新型隐球菌脑膜炎的５０％致死保护量（ＥＤ５０）为０．０５７～０．９４９ｍｇ／ｋｇ，与国外同类产品相当或更佳（０．０８～１．２５ｍｇ／ｋｇ）。提示国产氟康唑与进口制品相似，可用于人类的系统性真菌感染，尤其是对难治的新型隐球菌脑膜炎可获得较好疗效。
The antifungal effects of domestic fluconazoie were studied both in vitro and in vivo. In vitro, the antifungal action of fulconazole to 31 strains of Candida albicans (MIC 0. 8--200 mg/L), 24 strains of Cryptococcus neoformans (MIC 2. 24 -- 35. 4mg/ L)and some dermatophytes showed good fungistatic action. The MIC, MIC50 and MIC90 are similar to those of fluconazole (0. 2 ~ > 100mg/L, 3.13 ~ 12. 5ing/L ). The antifungal effect to Penicillium marneffei is also very good (MIC 3. 125mg/L ), which is the preliminary report in the literature. In vivo, the ED50 of fluconazole to meningitis caused by Candida albicans and Cryptococcus neoformans was 0. 057 pew 0. 949mg/kg which reveals even more effective than fluconazole. These results show that the antifungal effects of domestic fluconazole are more or less similar to those of imported fluconazole. it suggests that fluconazole may be effective for the treatment of human systemic fungal infections especially for the treatment of obstinate cryptococcal meningitis.
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
1994年第2期80-82,共3页
Chinese Journal of Dermatology
关键词
氟康唑
新型隐球菌
白念珠菌
Fluconazole Cryptococcus neoformans Candida albicans
