摘要
目的探讨大鼠坐骨神经断裂修复后吻合处不同时期的力学性能变化。方法以大鼠坐骨神经为实验对象,离断后端端外膜缝合,于术后即刻、1、3、6周采用拉伸实验进行生物力学测试,观察神经吻合处的拉伸最大强度的变化。结果大鼠坐骨神经横断修复后仍具有正常神经相似的负荷位移曲线,经t检验,术后即刻组同术后1周和3、6周组的拉伸最大负荷差异有统计学意义(t值分别为t术后即刻-1周=5.577,t术后即刻-3周=5.747,t术后即刻-6周=8.931,P均<0.01)。术后1、3、6周组间差异无统计学意义(t术后1周-3周=0.259,t1周-6周=0.677,t3周-6周=0.364;P均>0.05)。术后即刻组、1、3、6周组同正常坐骨神经差异有统计学意义(t值分别为20.701,6.357,5.890,7.016,P均<0.01);术后即刻组的拉伸最大负荷仅为正常神经的9%,术后1周拉伸最大负荷为正常神经的48%,而到术后6周为54%。结论大鼠坐骨神经损伤修复后仍具有粘弹性的特点,神经重获结构强度的速度非常快,且主要在神经修复后的1周内获得,并能在6周内维持拉伸最大强度的相对稳定。
Objective To observe the biomechanic properties of sciatic nerve at the suture site in rats following repairing. Methods The right sciatic nerves of 40 white Sprague-Dawley 300—350 gm rats were exposed,cut and then repaired with 10-0 nylon sutures, laced in the epineurium. 0、 1、3、6 weeks after operation, the tensile strength of the sciatic nerves were measured, the data analyzed statistically. Results (The load-elongation) curves for both the normal unoperated and operated nerves had the similar shape. The tensile strength of the 0week was significant difference to 1、3 and 6 weeks (P<0.01). No significant difference was found among 1、3 and 6 weeks. Conclusion The tensile strength of the injured nerves are recovered in the first week and resistant in 6 weeks after repairing.
出处
《中华外科杂志》
CAS
CSCD
北大核心
2005年第12期792-794,共3页
Chinese Journal of Surgery
