摘要
对１０例输血后丙型肝炎进行了病毒血症、抗体及丙氨酸转氨酶（ＡＬＴ）动态研究。用套式ＰＣＲ法检测丙型肝炎病毒（ＨＣＶ）ＲＮＡ，首次检出时间为输血后１５～８７天，平均４０．３±２０．１天，持续或间歇阳性超过１年者７例。抗ＨＣＶＣ１００．Ｎ１４、Ｐ２２和ＳｃＮＳ３／４和５抗体首次阳转时间分别为输血后３３～４３７（１１９．７±１１９．５）天、５２～１６６（７７．９±３５．６）天、３３～１０３（５５．０±２３．８）天和３３～６６（４０．１±１３．５）天，该４种抗体阳转后都持续１年以上。ＡＬＴ首次异常时间为输血后１５～６０天，平均３７．９±１３．９天，异常超过１年者６例。
A dynamic study on 10 cases of post transfusion hepatitis C viraemia, antibody and alanine transminase was carried out.The positive HCV RNA was first detected at 15-87 days, by 'nested'PCR, with an average of 40.3±20.1 days after transfusion,and sustained and intermitted positive more than one year in 7 cases. Sero positive conversion of anti-HCV C100-3,N14,P22 and Sc NS3/4.5 were at 33-437 (119.7 ±119.5)days,52-166(77.9±35.6)days,33-103(55.0±23.8) days and 33-60(40.1±13.5)days, after transfusion, respectively, and all 4 anti-HCV persisted for more than one year once they became positive.The abnormal ALT was first detected at 15-60 days,with an average of 37.9±13.9 days after transfusion, and persisted for more than one year in 6 cases.
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
1994年第4期340-343,共4页
Chinese Journal of Experimental and Clinical Virology
基金
国家科委"八五"河北省卫生厅及省科委资助
关键词
丙型肝炎
丙型肝炎病毒
抗体
转氨酶
病毒血症
Hepatitis C,Hepatitis C virus (HCV) RNA, Anti-HCV,Alanine transminase,Dynamic
