摘要
应用一组单克隆抗体（单抗），采用免疫荧光法分析了２１８例急性髓系细胞白血病（ＡＭＬ）患者细胞的免疫表型。结果提示ＣＤ＿（３３）、ＣＤ＿（１３）和ＣＤ＿（１５）为ＡＭＬ的主要标记；免疫分型在一定程度上有助于ＡＭＬ各亚型的鉴别。强调指出：在ＡＭＬ和急性淋巴细胞白血病（ＡＬＬ）鉴别时，ＣＤ＿（３３）、ＣＤ＿（１３）和ＣＤ＿（１５）应联合应用。配以胞浆抗原的检测，将是ＡＭＬ和ＡＬＬ鉴别时行之有效的髓系单抗选择方案。
he immunophenotypes of 218 cases of acute myeloidleukemia (AML) were analysed with a panel of mono-clonal antibodies by immunofluorescent method. The re-sults showed that: 1. 65%, 63% and 47% of patientswere and CD respectively , which are majorcell surface markers of AML; 2. immunophenotypingmay be helpful for distinguishing subtypes of AML; 3.CD_(33),CD_(13) and CD_(15) must be used in combination in thedifferentiation of AML from ALL. Detection of cyto-plasmic antigen is very useful for the diagnosis of CDCD , CD AML.
出处
《中华血液学杂志》
CAS
CSCD
北大核心
1994年第9期466-468,共3页
Chinese Journal of Hematology
关键词
白血病
单克隆抗体
免疫分型
诊断
Acute myeloid leukemia Monoclonalantibody Immunophenotype Dif-ferential diagnosis Selection of mon-oclonal antibody
