摘要
应用聚丙烯酰胺凝胶等电聚焦酶免疫检测技术，调查了成都地区汉族群体凝血因子ＸⅢＡ和ＸⅢＢ的遗传多态性。等位基因频率为：Ｆ Ａ＊１＝０．８７１９，Ｆ Ａ＊２＝０．１２４０，Ｆ Ａ＊３＝０．００４１；Ｆ Ｂ＊１＝０．２７２７，Ｆ Ｂ＊２＝０．０１６５，Ｆ Ｂ＊３＝０．７１０７，Ｆ 表现型频率分布符合Ｈａｒｄｙ－Ｗｅｉｎｂｅｒｇ平衡定律。与国外其他群体的资料相比较，中国人Ｆ Ａ＊１和Ｆ Ｂ＊３等位基因频率相对较高。
Coagulation factor XⅢ A and XⅢ B polymorphisms in a random population sample from Chengdu in southwest China(n=121)were studied using isoelectric focusing in polyacrylamide gels followed by immunoblotting with enzyme immunoassay, The allele frequencies were: F XⅢ A *1=0.8719,F XⅢ A * 2=0.1240, FXⅢ*A 3=0.0041;FXⅢB*1=0.2727,FXⅢB*2=0.0165,FXⅢB*3=0.7107.Comparing these allele frequencies with those reported in other populations, we found that the allele frequencies of FXⅢ A *1 and F XⅢ B * 3 in the Chinese population were higher.
出处
《中华医学遗传学杂志》
CAS
CSCD
北大核心
1994年第5期267-269,共3页
Chinese Journal of Medical Genetics
基金
国家自然科学基金
纽约中华医学基金
关键词
凝血因子
多态性
等电聚焦
酶免疫检测
Coagulation factor X Ⅲ A Coagulation factor X Ⅲ B Genetic polymorphism Isoelectric focusing
