摘要
将２７例携带恶性疟配子体的患者，分为Ａ、Ｂ、Ｃ３组，Ａ组日服青蒿素１２００ｍｇ共５天，Ｂ组顿服甲氟喹７５０ｍｇ，Ｃ组顿服甲氟喹７５０ｍｇ＋伯氨喹４５ｍｇ。服药后按计划逐日取血观察配子体密度变化，同时观察配子体对大劣按蚊的感染情况。结果显示：Ａ组服药后４、７、１４和２ｌ天配子体密度和按蚊感染率下降非常显著，７天以后配子体感染性明显下降；Ｂ组７、１４和２１天配子体密度显著减少，１４天和２ｌ天配子体感染性和按蚊感染率下降非常明显；Ｃ组９例４天时有５例配子体消失，全部不能感染蚊媒。说明青蒿素对恶性疟配子体感染性有抑制作用，在阻断恶性疟传播途径方面的作用明显优于甲氟喹。
7 patients
with gametocytes of P. .falciparumwere divided into groups A, B and C. 1200 mg ofartemisinin
was given as a daily dose for 5 days togroup A, 750 mg of mefloquine as a single dose togroup
B, and 750 mg of mefloquine plus 45 mg ofprimaquine as a single dose to group C.
Aftermedication, gametocyte count was observed daily inaddition to the infectivity of
gametocytes of P.falciparum to Anopheles dirus. In group A, the densityof gametocytes and the
infectivity were significantlyreduced on days 4,7,14 and 21 during the study. Ingroup B, the
density of gametocytes was significantlyreduced on days 7, 14 and 21 and the infectivity
wasobviously lowered on days 14 and 21 after medication.In group C, gametocytes disappeared
in 5 out of 9 pa-tients with the failure of infection to mosquitoes onday 4 after treatment. This
indicates that artemisinincan effectively influence the infectivity of gametocytesof P. falciparum.
Artemisinin is superior to mefloquinein blocking the transmission of P. falciparum malaria.
出处
《中华医学杂志》
CAS
CSCD
北大核心
1994年第4期209-210,共2页
National Medical Journal of China
关键词
疟疾
青蒿素
疟原虫
Artemisinin GametocytePlasmodium falciparum Infectivity Anophelesdirus
