摘要
对１７例急性白血病患者在完全缓解期，采用低分子天然肿瘤抑制物体外培养净化后进行了自体骨髓移植，其中急性髓细胞白血病１４例，急性淋巴细胞白血病３例，预处理以环磷酰胺和全身照射为主。移植后未接受抗白血病治疗，随访观察１５至４５个月，１１例无病生存１５个月以上，８例２４个月以上，５例３０个月以上，最长１例为４３个月。５例在６～２２个月复发，１例在６个月猝死。统计３．５年无病生存率为６２．７％±１５．０％
ourteen patients with acute myelogenousleukemia and 3 patients with acute
lymphoblasticleukemia in complete remission underwent autologoustransplantation of their
bone marrow cells inlong-term culture containing low molecularweight-natural tumour
suppressor. Their mean agewas 27 years (9～35). Preparative regimen
includedcyclophosphamide and total body irradiation. All pa-tients received no chemotherapy
after transplantation.Follow-up for to 45 months showed that 11 patientsremained disease-free
survival (DFS) at 15 months, 8at 24 months, 5 at 30 months, and 1 at 43 months. 5patients
relapsed between 6 and 22 months. One casedied from sudden death at 6 months. 3.svear
DFSwas 62.7 ±1 5.0% .
出处
《中华医学杂志》
CAS
CSCD
北大核心
1994年第5期287-289,共3页
National Medical Journal of China
关键词
骨髓移植
自体
白血病
急性
Bone marrow transplantation,autologous Leukemia, acute
