摘要
１９８７年５月～１９９０年３月，我们对１６８例有病理诊断依据的男性原发性肺癌患者进行１：２配比的病例对照研究。吸烟史、职业和有害物质接触史，做饭燃料和取暖方式按时间顺序收集资料。采用前向分析与后向综合的分析方法，计算累积有效暴露得分和额外暴露得分，在完成状态风险分析的同时实现潜伏期分布的研究。研究结果表明，室内空气污染（潜伏期为５４．５年）致肺癌的危险可能高于总吸烟（５６．２年），在多因素效应下，致肺癌潜伏期可以改变，提示癌症可以通过延长潜伏期得到控制，尤其对致癌因子不可能完全消除的肿瘤更为重要。
Abstract A
case-control study time-related factors was conducted to estimate the latency period oflung
cancer. This study included 169 incident male cases of lung cancer histologically confirmed
and336 control patients with non-neoplastic diseases. All patients were interviewed in the
hospital wardsfrom May 1987 to May 1990. Data concerning smoking, occupation, method of
house heating andcooking fuel used from twelve time windows of looking forward and diet were
obtained for three periodsof time. A synthetical analysis of forward measures and backward
measures were applied. By means ofcalculating accumulated effective exposure score and
excess exposure fraction, the latency period of lungcancer was estimated using multivariate
model. Latency of lung cancer is 54.48 years for indoor airpollution, and 56.17 years for total
smoking. From estimating latency period of lung cancer frommultivariate analysis, it was found
that the latency of lung cancer could be affected by the effects of other factors. Therefore,
measures which prolong latency period may be of use in the prevention of lungcancer.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
1994年第1期19-21,共3页
Chinese Journal of Oncology
