摘要
目的研究低分子甲壳铵在小鼠体内的吸收及其在组织中的分布。方法采用氚标记法,测定低分子甲壳铵灌胃后的血药浓度,药动学参数采用DASver1.0程序计算,观察其在小鼠体内的组织分布。结果低分子甲壳铵药动学符合二室模型,在肾、肝、脾中分布较高,其在肿瘤组织中的分布显著高于正常小鼠同一部位的肌肉组织。结论低分子甲壳铵口服可吸收,并易于与肿瘤结合,有望开发成为一种口服抗肿瘤药。
Objective To study the absorption and distribution of low molecular N-trimethyl chitosan chloride in mice.Methods Using tritium marking method to determine the concentrations of low molecular N-trimethyl chitosan chloride in serum after oral administration.Its pharmacokinetics were analysed by DAS ver1.0 program and the distributions in tissues were examined. Results The pharmacokinetics of low molecular N-trimethyl chitosan chloride were consistent with two-compartment model.The radioactive concentrations in liver,kidney,lung and spleen were higher than those in other tissues.And the radioactive concentration in cancer was higher. Conclusion Low molecular N-trimethyl chitosan chloride could be absorbed after oral administration.It was easily conjugate with cancer surface and could be developed as an anticancer drug for oral use in the future.
出处
《中国海洋药物》
CAS
CSCD
2005年第3期15-17,共3页
Chinese Journal of Marine Drugs
关键词
低分子甲壳铵
体内吸收
体内分布
low molecular N-trimethyl chitosan chloride
body absorption
body distribution
