摘要
应用单克隆抗体ＭＣ５对１５６例大肠息肉进行免疫组化检测，腺瘤性息肉９６例，阳性４３例，占４４．８％，非腺瘤性息肉６０例，阳性６例，占１０％，两组相比有显著统计学意义（Ｐ＜０．０１）。在肿瘤性息肉中，绒毛状腺瘤阳性率为６８．２％（１５／２２），绒毛管状腺瘤阳性率为３８．９％（７／１８），管状腺瘤阳性率为３７．５％（２１／５６），它们三者之间无显著统计学意义（Ｐ＞０．０５）。这说明腺瘤性息肉与非腺瘤性息肉在肿瘤抗原表达上有差异。腺瘤性息肉伴不典型增生５９例，其中轻度不典型增生１１例，阳性６例（５４．５％），中度和重度不典型增生４８例，阳性３８例（７９．２％）。本组结果表明，腺瘤性息肉伴不典型增生与ＭＣ５的阳性率相平行，反映出它们的恶变趋势。提示早期切除腺瘤性息肉，对预防大肠癌的发生具有重要意义。
Ninety six colonic adenomatous polyps and 60 non-adenomatous polyps were studied with immunohistochemical method by using monoclonal antibody MC5. The positive staining rates in these two groups were 44.8% (43/96)and 10% (6/60) respectively(P<0.01). The result indicated that an essential distinction of tumor antigen expression existed in adenomatous and non-adenomatous polyps. Among the 59 cases of adenomatous polyps with dysplasia,6/11(54.5%)cases with mild dysplasia were positive, and 38/48(79.2%)cases with medium and severe dysplasia were positive. It was suggested that the adenomatous polyps with dysplasia ran parallel to MC5 positive staining and to the carcinogenesis tendency.
出处
《肿瘤》
CAS
CSCD
北大核心
1994年第5期255-257,共3页
Tumor
关键词
单克隆抗体
免疫组织化学
大肠息肉
Monoclonal antibody
MC_5 Immunohistochemistry
Colonic polyps
