摘要
目的 探讨降钙素原(PCT)和C反应蛋白(CRP)浓度检测对诊断新生儿败血症的灵敏度和特异性,为临床提供准确快速的诊断依据。方法 用半定量固相免疫层析法和免疫浊度法分别测定23例新生儿败血症患儿的血清PCT和CRP浓度,并与白细胞(WBC)计数进行比较。结果 PCT、CRP对诊断新生儿败血症的灵敏度均高于WBC计数(P<0. 05), 3个指标中,PCT的灵敏度、特异性、阳性预测值、阴性预测值、准确性性和约登指数最高。PCT与CRP间呈显著正相关(P<0. 01)。结论 PCT和CRP浓度检测对新生儿败血症的早期诊断有一定价值。
Objective To explore the diagnostic sensitivity and specificity of procalcitonin (PCT) and C-reactive protein (CRP) for neonatal sepsis. Methods 23 serum samples of neonatal sepsis were measured for PCT by semi-quantitative solid-phase immunochromatography and CRP by immunoturbdimetry assay and was tested for comparison white blood cell count(WBC). Results PCT and CRP had higher sensitivity than WBC (P<0.05). PCT had highest sensitivity, specificity, positive predictive value, negative predictive value, accuracy and youden's index for diagnosing neonatal sepsis. There was positive correlation between PCT and CRP. Conclusions Determination of PCT and CRP is valuable for the diagnosis of neonatal sepsis.
出处
《检验医学》
CAS
北大核心
2005年第3期250-252,共3页
Laboratory Medicine
