摘要
用组织学和组织化学方法，观察了下颌下腺切除对大鼠胃粘膜结构和代谢活动的影响。结果显示，下颌下腺切除术后１０ｄ，胃体和胃窦粘膜均明显薄于对照组（Ｐ＜０．０１）（分别减少１６．６３％和１９．７７％）；壁细胞数量无明显变化。术后１０～２８ｄ，胃粘膜酸性粘液物质有所减少。术后４～２８ｄ，胃粘膜表面粘液细胞和膝上皮细胞Ｆｅｕｌｇｅｎ染色均减弱。术后２～１０ｄ，壁细胞内ＳＤＨ活性增强，至术后２１ｄ恢复正常。术后２ｄ，胃粘膜毛细血管内皮细胞Ｍｇ＋＋－ＡＴＰａｓｅ活性略增强；术后１０～２８ｄ，活性略减弱。胃粘膜表面粘液细胞和晚上皮细胞ＡｃＰ活性在术后４～２１ｄ增强，术后２８ｄ恢复正常。本实验结果提示，下颌下腺的某些生物活性物质是维持胃粘膜正常结构和代谢活动的必需因素，其中表皮生长因子或许更为重要。
The effects of extirpation of submandibular gland on the structure and metabolic activities of the gastric mucosa were examined in the rats by using histological and histochemical methods.On 10th day after the extirpation,the thickness of corpus and antral mucosa was notably decreased by l6.63% and l9.77% as compared with normal control group(P<0.0l);the number of parietal cells did not vary,From l0 to 28 days after operation,acid mucus in gastric mucosa was reduced.Day 4 later,the content of DNA was decreased.On 2nd day after operation,the reactivity of SDH and Mg++ -ATPase in gastric epithelium was slightly increased and then became weakened.However,the reactivity of SDH in parietal cells was enhanced before day l0 and recovered to normal on day 21.The intensity of AcP was stronger than that of the normal control from day 4 to day 21.The results show that some biologically active polypeptides,especially EGF,in submandibular gland are essential trophic and protective factors to gastric mucosa.
出处
《解剖学报》
CAS
CSCD
北大核心
1994年第3期318-322,T017,共6页
Acta Anatomica Sinica
关键词
胃粘膜
颌下腺切除
组织化学
Gastric mucosa
Extirpation of submandibular gland
Histochemistry
Histology
Rat
