摘要
目的研究维生素E烟酸酯(简称VEN)自乳化制剂,探求其最佳处方配比。方法通过溶解度实验、正交筛选和假三角相图的绘制,以形成自乳化区域的大小、溶出度和所得乳滴粒径的大小为指标,对VEN自乳化制剂中的油相、乳化剂及助乳化剂的组成、用量进行筛选,找出最佳的搭配和处方配比。结果在VEN自乳化制剂处方中,以油酸乙酯为油相,聚氧乙烯蓖麻油(EL20)为乳化剂,乙二醇单乙基醚(transcutol)为助乳化剂时,可以获得较好的乳化效果。结论VEN自乳化制剂的最佳处方比例为m(VEN)∶m(油酸乙酯)∶m(EL20)∶m(transcuto1)=1∶0.75∶1.35∶0.9。
Objective To search for the optimum formula for the self-emulsification of vitamin E nicotinate.Method Through solubility experiment,orthogonal screening and drawing phase diagram,taking the area of effective self-emulsifying in phase diagram,dissolution and emulsion particle size as parameters,oil,non-ionic surfactant and co-surfactant were screened for the best formula.Results In the formula of vitamin E nicotinate SEDDS,taking ethyl oleate as the oil,EL-20 as the surfactant and transcutol as co-surfactant can get the best effect of emulsifying.Conclusion The optimum formula for self-emulsification of vitamin E nicotinate is m(vitamin E nicotinate) ∶m(ethyl oleate)∶m (EL-20)∶m(transcutol)=1∶0.75∶1.35∶0.9.
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2005年第4期245-247,251,共4页
Journal of Shenyang Pharmaceutical University
关键词
维生素E烟酸酯
自乳化
剂型改进
vitamin E nicotinate
self-emulsifying
improving dosage form
