摘要
应用反相ＨＰＬＣ法测定血药浓度，对复方盐酸伪麻黄碱缓释片的体外溶出以及兔灌服一次的药物动力学进行了研究，并与自制普通片进行对照。结果表明缓释片维持体内有效血药浓度的时间较长，其相对生物利用度为１２２．４８％。体内外显著相关（Ｐ＜０．０１）。理论值与实测值基本相等（Ｐ＜０．０１）。
Using RP-HPLC method for determining the serum levels of pseudoephedrine hydrochloride(1.HCl), the dissolution rate of compound 1.HCl sustained-release tablets(SRT) and their pharmacokinetics in rabbits after oral administration of single dose were studied and compared with the ordinary tablets. The results showed that the compound 1 . HCl SRT released the drug with a first-order kinetics and a significant correlation was found between in vivo dissolution and in vivo absorption.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1995年第10期446-449,共4页
Chinese Journal of Pharmaceuticals
关键词
盐酸伪麻黄碱
缓释片
溶出度
生物利用度
pseudoephedrine hydrochloride
sustained-release tablets
dissolution rate
bioavailability
RP-HPLC
