摘要
目的观察5-氟脲嘧啶静脉输注,顺铂腹腔灌注联合全身热疗治疗恶性肿瘤肝转移的客观疗效及毒副反应.方法顺铂30mg/m2+生理盐水2000～3 000mL腹腔灌注,d1、dg,腹腔穿刺采用单次直接腹腔穿刺法.术后应用国产UHR-2000型微波热疗机进行深部热疗90min,5-氟脲嘧啶300mg/(m2.d)静脉输注,d2～6、d9～13,28天为一周期,2个周期以上评价疗效.结果全组16例,CR1例、PR 9例,近期有效率62.5%,无明显毒副反应.结论低剂量5-氟脲嘧啶静脉输注,顺铂腹腔灌注加全身热疗治疗恶性肿瘤肝转移是低毒有效的方法,值得临床推广应用.
Objective To observe the efficacy and side-effect of infusion 5-Fluorouracil and Cisplatin (DDP) interperitoneal chemoperfasion combined with hyperthermia to cure the hepatic metastasis of malignant tumor.Methods Cisplatin 0mg/m2+NS 2 000- 000 mL were drained in interperitoneal d_ 1,8,the method of direct single abdominal cavity's puncture was adopted. After the operation URH-2000 microwave thermotherapy machine was used to lead a ninety-minutes deep part hyperthermia. 5-Fluorouracil 00 mg/(m2.d) was infused for days from 2 to 6, and from 9 to 1. The schedule was repeated every 28 days. The efficacy and side-effects were analysed after two cycles or more.Result There were all the 16 sufferers, 1 obtained complete remission, 9 obtained partial remission, recent effect was 62.5%. There was no obvious side-effect.Conclusion It is a low side-effect method to cure the hepatic metastasis of malignant tumor with low dosage infusion 5-Fluorouracil and Cisplatin interperitoneal chemoperfasion combined with hyperthermia, it is worth generalization clinically.
出处
《河南肿瘤学杂志》
2005年第4期257-258,共2页
Henan Journal of Oncology
关键词
肝转移
5-氟脲嘧啶
顺铂
腹腔灌注化疗
热疗
hepatic metastasis
5-Fluorouracil
Cisplatin
interperitoneal chemoperfasion
hyperthermia
