摘要
目的探讨初诊为精神分裂症患者血清中IgG、补体C3、外周血T淋巴细胞亚群、外周血异常淋巴细胞形态等的改变情况。方法收集30份初诊为精神分裂症患者,21份正常献血员的血样。用BN-100特定蛋白分析仪检测血清IgG、补体C3。用FACSCalibur流式细胞仪检测T淋巴细胞亚群。用瑞氏姬姆萨法研究外周血白细胞形态学,计数P细胞、S细胞、正常淋巴细胞的百分比。结果精神分裂症患者的IgG和C3均低于正常对照组(P均<0.05),CD8+高于正常对照组(P<0.05),CD3+、CD4+与对照组比较无显著性差异(P均>0.05),各淋巴细胞百分率与对照组比较有显著性差异(P均<0.01)。结论精神分裂症患者多伴有免疫指标的异常及外周血淋巴细胞形态的异常,提示可用免疫调节剂辅助治疗本病。
Objective It is to discuss the changes of serum IgG, C3 complement, T lymphocyte subsets and atypical lymphocytes in first visit schizophrenic patients. Methods The blood samples of 30 cases of first visit schizophrenic patients and 21 cases of healthy blood donors were collected. BN-100 special protein analysor was used to detect serum IgG and C_3 complement. FACS Caliber flow cytometry was used to detect T lymphocyte subsets. May Grunwald-giemsa staining was used to detect cell morphology. The percentages of P cell, S cell and normal lymphocyte were recorded.Results In 30 schizophrenic patients, IgG and C_3 were lower than that in normal control group (P<0.05), CK_8 + was higher than that in normal control group (P<0.05), CD_3 and CD_4 were not significantly different with that in normal control group (P<0.05) and the lymphocyte percentages were significantly different with that in normal control group (P<0.01). Conclusion There were abnormal immune indexes and abnormal blood cell morphology in most schizophrenic patients, it showed that the disease maybe treated with immunoregulator.
出处
《现代中西医结合杂志》
CAS
2005年第15期1953-1954,共2页
Modern Journal of Integrated Traditional Chinese and Western Medicine
