摘要
目的运用自制10F导管胸腔闭式引流、短棒注射液胸膜腔封闭粘合术并局部与全身化疗治疗恶性胸腔积液,对其疗效做全面评价。方法运用自行设计与45号腹腔穿刺针套管配套的10F塑料导管(陕西邦盛医疗器械有限责任公司制造)治疗我科住院的134例恶性胸腔积液患者,男69例,女65例;年龄19～83岁。左侧52例,右侧72例,双侧10例;肺腺癌72例,肺鳞癌28例,肺小细胞未分化癌9例,卵巢癌2例,恶性淋巴瘤2例,乳腺癌1例,间皮瘤3例,结肠癌胸膜转移1例,未定类型16例。行胸腔闭式引流术,并注入短棒注射液胸膜腔封闭粘合术,注入顺铂、羟基喜树碱局部化疗,布比卡因局部止痛,常规全身化疗。结果患者恶性胸水治愈率76.1%(102/134),有效率100%;完全缓解率100%;副作用中胸痛发生率46.0%(59/134),胸廓塌陷发生率69.4%(93/134),发热34.3%(46/134),局部皮下结节发生率28.4%(38/134),肿瘤皮下转移14.2%(19/134),恶心呕吐31.3%(42/134),导管阻塞3.7%(5/134),众多并发症患者均可耐受,患者生存质量均明显提高。结论自制10F导管闭式引流、短棒胸膜腔封闭,并局部与全身化疗是治疗恶性胸腔积液良好而可靠方法,值得临床推广。
Objective Evaluating effect of united treatment of malignancy pleural effusion with closed drainage with self-restraint 10F canal, pleurodesis with corynebacterium parvm injection and chemotherapy. Methods Devised a 10F plastic canal deserving with 45's abdominal paracentetic needle and closed drainaged of 134 cases of patients with malignancy hydrothorax (male 69cases, female 65cases) and injected corynebacterium parvm injection and cis-dichlorodiamine platinum and hydroxy campto thecine and bupivacaine into pleural cavity ,then normally whole body chemotherapy. Results The cure rate of malignancy pleural of the patients was 76.1%(102/134)and effective rate was 100%. The completely remission was 100% according to Millar standard. There were many ill effect , rate of chest pain was 46.0%(59/134), rate of thorax sinking 69.4%(93/134), fever 34.3%(46/134), subcutaneous nodule 28.4%(38/134), metastasis subcutaneous tumor 14.2%(19/134), nausea and vomitus 31.3%(42/134), canal emphraxis 3.7%(5/134). The patients could all tolerant these ill effect and their life quality was all raised. Conclusion United treatment of malignancy pleural effusion with closed drainage with self-restraint 10F canal, pleurodesis with corynebacterium parvm injection and chemotherapy is an effective way. It is worthy spreading in clinic .
出处
《现代肿瘤医学》
CAS
2005年第4期519-521,共3页
Journal of Modern Oncology
关键词
闭式引流
化疗
胸腔积液
恶性
治疗
closed drainage
chemotherapy
hydrothorax
malignancy
treatment
