摘要
目的探讨白细胞介素4(IL4)(C589T)基因多态性与胆石病发病例因素的相关性。方法采用聚合酶链式反应限制性片段长度多态性分析(PCRRFLP)技术对中国南京地区81例胆囊结石患者和41例胆管结石患者进行IL4(C589T)基因型分析。结果胆囊结石组与胆管结石组患者IL4(C589T)基因型频率和等位基因频率有显著性差异(CC分别为11.1%和48.8%、CT分别为34.6%和36.6%、TT分别为54.3%和14.6%、C分别为28.4%和67.1%、T分别为71.6%和32.9%)。结论IL4(C589T)基因多态性与胆管结石的形成存在相关性,与胆囊结石不存在相关性。
Objective To investigate the relationship between IL-4 gene polymorphism and cholelithiasis in Chinese population. Methods Polymerase chain reaction combined with restriction enzyme digestion was used to detect the polymorphism of IL-4 gene in 81 cholecystolithiasis、41 patients with biliary duct stone. Results There were no significant differences of the IL-4 gene polymorphism genotypes and alleles between 81 cholecystolithiasis patients (CC11.1%、CT34.6%、TT54.3%;C28.4.7%、T71.6%). There were significant differences of the IL-4 gene polymorphism genotypes and alleles between 41 patients with biliary duct stone (CC48.8%、CT36.6%、TT14.6%;C67.1%、T32.9%). Conclusions The C589T polymorphism of IL-4 gene was not associated with cholecystolithiasis patients in Chinese,but was related to patients with biliary duct stone in Chinese.
出处
《中华外科杂志》
CAS
CSCD
北大核心
2005年第13期850-852,共3页
Chinese Journal of Surgery
