摘要
观察四种不同剂量咪唑安定的健忘、镇静及心血管抑制作用。结果表明，咪唑安定０．０８ｍｇ／ｋｇ，最大健忘率９０％，持续约５分钟。０．１０ｍｇ／ｋｇ１分钟健忘率达１００％，持续约１５分钟。０．１３、０． １６ｍｇ／ｋｇ分别于 １分钟和 ３０秒达１００％健忘，持续约３０分钟。≤ ０．１０ｍｇ／ｋｇ多数呈浅睡或嗜睡状态，少数呈深睡状态，无一例意识消失；血流动力学变化无统计学意义。≥０． １３ｍｇ／ｋｇ ６０％呈深睡状态，部分病例意识消失；ＳＰ、ＥＦ％、ＳＶＩ、ＣＩ明显降低，少数指标３０分钟时仍显著低于对照值。提示咪唑安定的健忘、镇静及心血管抑制作用与剂量相关，作为健忘镇痛复合麻醉手术，咪唑安定用量以０．１０ｍｇ／ｋｇ为宜。
To evaluate the amnestic effect of midazolam,eighty adult patients ; ASA grade I to ,scheduled to undergo abdominal or lower extremity operation, were randomly assigned to receiving intlavenous injection of midazlam at a dose of 0. 08(group I ), 0. 1 (group ), 0. 13 (group ) or 0. 16mg. kg-1 (group ) respectively with 20 cases in each group. The maximum incidence and duration of amnesia were determined respectively at 0. 5, 1, 5, 15, 30 and 60 min immediately following the administratin of midazolam in four groups by subject's recalling the characteristics of the picture,which was shown to the subject in 10 to 15 seconds before the injection of midazolam. The hemodynamic parameters wele observed by the impendance cardiography. The results showed that the Incidences of amnesia were 90%, 100% .100%, 100%,and its durations were 5, 15, 30 and 30 mins in group and individually. The hemodynamics kept statistically stable in group during the whole procedures (P>0. 05),and systolic blood pressure,cardiac index and systemic vascular index were decreased to and maintained at lower levels in 30 mln in group and (P<0.05 or 0. 01). It is suggested that midazolam may produce a dose--related amnetsic effects,and at a dose of 0.1mg. kg-1 is suitable for clinical combined anesthesia.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
1995年第10期453-455,共3页
Chinese Journal of Anesthesiology
