摘要
观察复制犬心肌缺血再灌注模型的血白细胞聚集率、脂质过氧化物（ＬＰＯ）、超氧化物歧化酶（ＳＯＤ）、过氧化氢酶（ＣＡＴ）及血流动力学指标和心肌超微结构的变化。结果显示：心肌缺血时白细胞聚集率增强，血ＬＰＯ含量增多，血ＳＯＤ和ＣＡＴ活力下降。再灌注后血白细胞聚集率增强更明显，同时血ＳＯＤ和ＣＡＴ活力进一步下降。血流动力学监测表明心功能明显低下。心肌超微结构损害明显。而用前列腺素Ｅ＿１（ＰＧＥ＿１）预防组血白细胞聚集率明显低于对照组，上述改变显著减轻。因而认为白细胞在心肌缺血再灌注过程中起着重要作用。ＰＧＥ＿１能够抑制ＰＭＮ活性，保护ＳＯＤ、ＣＡＴ活力，减轻ＬＰＯ的产生，改善心脏功能，对心肌缺血再灌注损伤有显著的保护作用。
he effect of prostaglandin E_1 ( PGE_1) on ischemia reperfusion injury ( IRI)was investigated. The changes of leucocytes in venous blood and infarcted myocardial tissue and the level of lipid peroxide (LPO),superroxide dismutase(SOD)and catalase(CAT ) were also studiedin these animal medels at the same time. The experimental results were as follows:the count and petivity of leucocvtes and the level ofLPO in IRI were obviously increased.The activity of SOD and CAT,nthe untreated group was much lower than that in the treat group (P<0.01).The infarcted size (IS)was larger in the untreated group.The count of leucocytes was positively related with the level of LPO and IS,but negatively related with the activity of SOD and CAT. However,the relationship disappeared after the administration of PGE_1.These data sug-gested that leucocyte plays an important role in IRI.PGE_1 can mhibit leucocyte activity,decrease peroxida-tion,reduce LPO preduction and increase the activity of SOD and CAT,It can decrease the infarct size.PGE_1 takes the main role in protecting IRI.
出处
《中华内科杂志》
CAS
CSCD
北大核心
1995年第2期98-101,共4页
Chinese Journal of Internal Medicine
