摘要
将亲代B/c鼠淋巴细胞经静脉途径输入到非照射性(C_(57)BL/6×BALB/c)F_1鼠体内,结果诱导出了抗dsDNA抗体和抗组蛋白抗体的持续升高,尿蛋白异常,并发生了免疫复合物介导的肾小球肾炎等系统性红斑狼疮样病变。输入淋巴细胞28天后,每天腹腔注射青蒿琥酯于F_1鼠体内,显示了青蒿琥酯可明显抑制疾病的发展。
SLE-like syndrome in (C57BL/6 x BALB/c) F1 mice can be induced by intravenous injection of lymphocytes from BALB/c parental mice. In these SLE-like mice levels of DNA antibody and anti—histone increased and there were immuno-complex mediated proteinuria, glomerulonephritis. 28 days later artesunate was given intraperitoneally to daily these mice. The results revealed that artesunate could significantly suppress the progression of disease activity,
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
1995年第1期17-19,共3页
Chinese Journal of Dermatology
