摘要
为评估解放后上海地区系统性红斑狼疮（ＳＬＥ）病人生存率的发展趋向和各种有关参数与病人预后的关系，对近３２年以来，在上海华山医院诊治并具有上海市户口的５６６例ＳＬＥ病人进行了生存率研究。以发病时间为计算起点，１年、５年和１０年的生存率分别为９２．６％［年末生存例数（５２４），年初观察例数（５６６），下同］、７２．７％（３７１，３８９）和６０．１％（２０４，２１０）。单因素分析表明，男性、神经精神症状、浆膜炎、高血压、贫血、淋巴细胞减少、血小板减少、蛋白尿、血尿、管型尿、血肌酐增高、血尿素氮增高、内生肌酐清除率降低、胆固醇增高、补体（Ｃ３）降低、狼疮细胞阳性、心电图异常和长期大剂量皮质激素治疗均是明显影响生存率的恶性因素。多因素分析表明，男性、血肌酐增高、Ｃ３降低和长期大剂量皮质激素治疗是独立影响因素。上述参数对评估ＳＬＥ发展趋势及ＳＬＥ病人预后有重要指导作用，血肌酐和Ｃ３水平可作为最佳参考指标。
To assess the impact of demographic and clinical factors on prognosis in patients with systemic lupus erythematosus (SLE), we examined the survivral rate by lifetable analysis in 566 patients. All patients were Shanghai citizens who were diagnosed as having SLE in Huashan Hospital between 1959 and 1992. According to American Rheumatism Association's preliminary criteria. The survival rate from the time of SLE onset was 93% at 1 year, 73% at 5 years and 60% at 10 years.On univariate analysis,we found that the following factors worsened the probability of survival; male, neuropsychiatric manifestation, pleurisy-pericarditis, anemia, thrombocytopenia, lymphocytopenia,proteinuria ,hematuria, urinary cast, azotemia,decreased endogenous creatinine clearance,increased cholesterol in serum, hypocomplementemia,abnormal electrocardiograph and high corticosteroid dose of treatment. On multivariate analysis, we found the four independent risk factors were male,azotemia ,hypocomplementemia and high corticosteroid dose of treatment.
出处
《中华医学杂志》
CAS
CSCD
北大核心
1995年第10期617-620,共4页
National Medical Journal of China
关键词
系统性红斑狼疮
预后
生存率
Lupus erythematosus,systemic Survival rate Survival prognosis
