摘要
本实验采用单摆式打击装置建立大鼠脑震荡模型。病理组织学改变为伤后１５分钟开始出现全脑血管痉挛，３０分钟血管痉挛缓解，进入持续性充血状态，相继出现神经细胞退变和部分轴索肿胀、断裂。测定了脑皮质中ＬＰＯ含量呈明显时序性改变，伤后３０ｍｉｎ开始上升（Ｐ＜０．０５）。６０ｍｉｎ达高峰。证明了脑震荡脑损伤的形成是在暴力直接作用所致损伤的基础上，伴以缺血再灌流损伤。
The cerebral concussion model was produced by simple pendulum striking device. Thecontent
of lipid peroxidation (LPO) and superoxice dismutase(SOD) in contex was measured and
thehitopathological change of the brain was observed.The content of LPO changed with time.
LPO in-creased after injury and reached the peak in 1 hour,the decreased.There was no
difference betweenthe content of SOD in the coneussion groups and the control group.The
blood vessel began spasm in15 min──30 min after injury.The congestion condition appeared
after the relief of spasm. The neuronsdegenerated and parts of the axons swelled ,broke,
These results showed that the spasm of vessels inbrain occured in 15 min──30 min after
damaging,then the reperfusion injury took place. The cerebraltissue was irreversibly damaged
by the poisoning of LPO on the basis of slightly reversible injury bystriking.
出处
《白求恩医科大学学报》
CSCD
1995年第2期134-136,共3页
Journal of Norman Bethune University of Medical Science
