摘要
用放射免疫分析技术测定大鼠在６００ｋＰａ高压氧暴露下海马、纹状体和额叶皮质中生长抑素（ＳＳ）含量的变化，并在７００ｋＰａ高压氧暴露下，观察腹腔内注射半胱胺（ＣＳＨ）及侧脑室内注射ＳＳ抗血清对大鼠氧惊厥始发时间（Ｉｎｉｔｉａｌｔｉｍｅｏｆｃｏｎｖｕｌｓｉｏｎ；ＩＴＣ）、惊厥严重程度（Ｓｅｖｅｒｉｔｙｏｆｃｏｎｖｕｌｓｉｏｎ；ＳＯＣ）和氧惊厥大鼠存活时间（Ｓｕｒｖｉｖａｌｔｉｍｅ；ＳＴ）的影响。结果显示大鼠濒临氧惊厥时海马、纹状体中ＳＳ含量显著升高，氧惊厥时所观察脑区ＳＳ含量均显著升高；ＣＳＨ和ＳＳ抗血清预处理显著延迟大鼠ＩＴＣ，减轻ＳＯＣ和延长其ＳＴ。提示ＳＳ可能参与氧惊厥发作过程，并可能是导致氧惊厥的内源性物质之一。
The content of somatostatin (SS) in hippocampus,striatum and frontal cortex tissues of rats exposed to 600 kpa hyperbaric oxygen was determined by means of radioimmunoassay.Initial time of convulsion, severity of convulsion and survival time of rats with convulsion exposed to 700 kpa hyperbaric oxygen after intraperitoneal injection of cysteamine or intracerebroventricular injection of anti-somatostatin serum were also observed.The results showed that the content of SS in hippocampus and striatum tissues increased markedly before rats were at unconvulsion, by the time rats developed convulsion,it had a significant increase in all of the brain areas observed. Intraperitoneal injection of cysteamine or intracerebroventricular injection of anti-somatostatin serum could delay initial time of convulsion,prolong survival time and decrease severity of convulsion.These results suggest that SS might play a role in oxygen-induced convulsion and be one of the endogenous agents which caused oxygen-induced convulsion.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1995年第6期524-524,共1页
Academic Journal of Second Military Medical University
关键词
生长抑素
氧惊厥
海马
纹状体
高压氧
氧中毒
somatostatin
oxygen-induced convulsion
cysteamine
antiserum
hyperbaric oxygen
hippocampus
striatum
frontal cortex
rats
