摘要
将茯苓多糖（ＰＰＳ）、刺五加多糖（ＡＳＰＳ）、银耳多糖（ＴＦ）、香菇多糖（Ｌｅｎｔｉｎａｎ）与Ｓ＿１８０细胞膜、（γ－￣３２Ｐ）ＡＴｐ－同温育，抽提并分离肌醇磷脂进行放射自显影和液闪计数。结果表明茯苓多糖，刺五加多糖对Ｓ＿１８０细胞膜网脂酰肌醇（ＰＩ）转换有显著抑制作用，刺五加多糖对其抑制作用与剂量呈正相关。银耳多糖、香菇多糖对ＰＩ转换无影响。
Mice sarcoma S_180 cell membranes,[γ-32]ATP and
plant polysaccharide(PPS,ASPS,TF orlentinan)were incubated together for 5 min at 30
℃,Phosphatidylinositides were extracted and isolated,and radioactivity was measured with
liquid scintillation counter.The results showed that PPS and ASPS,especially the latter,could
inhibit the phosphatidyinostol turnover obviously,while TF and lentinan hadno such effect
Combining with our previous findings that PPS and ASPS could inhibit the proliferation ofS_180
cell significantly while TF and lentinan had no such effect,we conisider that the antitumor
mechanismof plant polysaccharides(PPS and ASPS)may be related to the inhibition of
phosphatidyinositol turnover.
出处
《第一军医大学学报》
CSCD
1995年第3期211-212,共2页
Journal of First Military Medical University
基金
1992年度全军青年科学基金
关键词
植物多糖
肉瘤
磷脂酰肌醇
伏苓
银耳
香菇
plant polysaccharide
tumor
cell membrane
phosphatidyinositides
