摘要
通过建立强迫体位动物模型，对强迫体位所致肌肉损伤的生物标志物进行了研究，结果表明，动物腰部固定后，血清肌酸磷酸激酶（ＣＰＫ）在实验第１天便显著升高，且在整个实验期间均保持较高水平（Ｐ＜０．０１，Ｐ＜０．０５）；而其血清乳酸脱氢酶（ＬＤＨ）和Ｋ＋仅在固定早期升高（Ｐ＜０．０５），随后逐渐恢复到正常水平。全血乳酸仅在实验末期（第７周）显著升高（Ｐ＜０．０５）。结果提示，强迫体位可对肌肉造成一定程度的损伤，血清ＣＰＫ有可能作为强迫体位所致肌肉损伤的生物标志物。
In order to study the biomarkers of muscle damage induced by constrained body posture, an animal model of constrained posture was established in laboratory. The levels of whole blood lactic acid (LA),serum CPK, LDH and K+ were determined in different time. The results showed that the levels of serum CPK,LDH and K+increased significantly in the first day after being constrained (P<0. 01, P<0. 05);the level of blood LA was markedly high in the 7th week after being constrained(P<0. 05). The levels of serum CPK were all significandy higher than those of controls during whole experiment period. However, the levels of LDH and K+ resumed to preconstrained level. These results suggested that constrained body posture could cause muscle damage, and serum CPK could be considered as a biomarker of muscle damage induced by constrained body posture.
出处
《工业卫生与职业病》
CAS
CSCD
1995年第2期98-100,共3页
Industrial Health and Occupational Diseases
基金
国家自然科学基金
