摘要
用ＡＢＣ免疫组织化学方法，对南宁地区居民中１３例肝细胞性肝癌（ＨＣＣ）的活检组织进行研究。发现其中８例有突变型Ｐ５３蛋白呈强阳性表达，占ＨＣＣ病例数６４．３％。南宁地区某些县，如扶绥县是我国著名的ＨＣＣ高发区，不但ＨＢＶ感染率高，而且是全国少有的ＡＦＢ１高污染区，后者的作用不能忽视。与江苏启东和南部非洲ＨＣＣ高发区一样，估计也会出现ｐ５３基因突变热点。
Immunohistochemistry ABC method was used to study 13 biopsy casses of hepatocellular carcinoma (HCC) in Nanning prefectural district. Eight cases (64. 3%) were found to have positive expression of p53 mutation protein. Fu-Sui and its surrounding counties in the district are notorious for their high HCC incidence in China, not only high in infection of hepatitis B Verus (HBV) but also high in contamination of aflatoxin B1 (AFB1 ), and both are putative risk factors of HCC. The AFB1 could injure the DNA and cause a mutational hotspot in the p53gene. Thus its effect should not be neglected.
出处
《广西科学》
CAS
1995年第1期55-57,共3页
Guangxi Sciences
