摘要
作者用流式细胞计量术检测了３９例二倍体乳腺癌细胞的增殖活性和非克隆性异倍体细胞的分布。结果表明，二倍体乳腺癌细胞的ＳＰＦ、ＰＩ、＞２Ｃ％、＞４Ｃ％、ＤＮＡ量值分布、Ｇ（０／１）峰ＣＶ值和Ｇ（０／１）峰倾斜度等指标均明显高于正常对照组（Ｐ＜０．０１或Ｐ＜０．０５）。这些指标与患者淋巴结转移和临床分期的关系密切。淋巴结转移阳性病例的ＳＰＦ、＞２Ｃ％、＞４Ｃ％、Ｇ（０／１）峰ＣＶ值和Ｇ（０／１）峰倾斜度均显著高于淋巴结转移阴性者（Ｐ＜０．０５）。随临床分期增加，其＞４Ｃ％呈逐渐增高的变化（ｒ＝０．９９３，ｒ＞ｒ（０．０５））。这表明，二倍体乳腺癌细胞生物学特性与正常对照细胞有明显不同。它不仅有较高的增殖活性，而且还含有一些非克隆性异倍体细胞。
Proliferous activity and non-clone aneuploidy of tumor cells were measured by flowcytometric method on 39 patients with diploidy breast cancer.The results showed that SPF(S-Phase fraction),PI (proliferous mdes),>2C% (high diploidy cells percentage),>4C%(high tetraploidy cells percentage),distributing limit of cellular DNA content,CV anddeviated degree of diploidy cells G0/1 peak in diploidy tumor were higher than those in control(P<0.01 or P<0. 05).These targets of the patienst were closely related to LNM andclinical stages of disease. SPF,>2C%,>4C%,CV and deviated degree of G0/1peak in LNM(+)cases were higher than those in LNM(-)cases(P<0.05).The 4C% increased as theclinical stages of disease in diploidy breast cancer patients went up (r=0.993,r>r0.05).Thisshowed that the biological characteristics of diploidy tumor cells were quite differrent withthose of normal diploidy cells.They had not only higher proliferous activity, but also noncline aneuploidy cells.
出处
《河南肿瘤学杂志》
1995年第2期81-83,共3页
Henan Journal of Oncology
