摘要
应用酶联免疫吸附法测定了３４例慢性肺心病急性期患者、３３例慢性支气管炎急性期患者及３０例对照组病人血清髓鞘碱性蛋白（ＭＢＰ）的含量。结果表明：肺心病组患者血清ＭＢＰ显著高于慢支炎组与对照组（Ｐ＜０．００１）．而慢支炎组与对照组则无明显差异（Ｐ＞０．０５）。经直线相关分析发现ＭＢＰ的含量与ＰａＣＯ＿２呈明显正相关，与ＰａＯ＿２及ｐＨ尚无明显相关性，提示ＭＢＰ的升高可能与低氧及高碳酸血症对脑组织的损伤有关。
With a sensitive enzyme-linked im-munoadsorbent assay that can detect as little as 0.5ng/ml of myelin basic protein(MBP),we studied serum specimens from 34 patients with chronic cor pulmonale(CP)and 33 patients with chronic bronchi-tis(CB) during acute attack in hospital and 30 control subjects. The results showed that the serum mean MBP level of CP patients was markedly higher thanthose of CB patients and controls(P<0. 01 ),but nostatistically significant differences were found betweenCB patients and controls(P>0.05).There was apositive correlation between elevated levels of servmMBP and carbon dioxide partial pressure(PaCO_2).This suggested that elevated serum MBP levels may beassociated with brain destruction by hypercapnia andhypoxia of CP patients.
出处
《华西医科大学学报》
CSCD
1995年第2期138-140,共3页
Journal of West China University of Medical Sciences
基金
国家自然科学基金
四川省科委科研基金
关键词
肺心病
支气管炎
髓鞘碱性蛋白
病理化学
Chronic cor pulmonale Chronic bronchitis Myelin basic protein
