摘要
目的分析系统性红斑狼疮(SLE)患者结核菌感染的临床表现、特点以及相关危险因素。方法回顾分析了37例SLE结核感染住院患者和65例随机抽取的SLE对照组患者的临床资料,所有患者均有完整的病史、体格检查、实验室等辅助检查的资料。结果在37例SLE结核感染患者中,肺结核13例(35%),肺结核合并其他部位结核者7例,肺外结核17例。与对照组相比,结核感染组的日平均激素的剂量和细胞毒药物使用较高,在两组之间差异有统计学意义,而性别、年龄、病程、白蛋白/球蛋白、补体和激素冲击治疗等方面,两组间差异无统计学意义。讨论SLE患者发生肺外结核感染的机会较大,且日平均激素的剂量和细胞毒药物是SLE患者发生结核感染的危险因素。
Objective To describe the clinical features and the course of tuberculosis in patients with systemic lupus erythematosus and to determine the risk factors associated with it. Methods The medical records of 37 SLE patients with tuberculosis and 65 SLE patients were reviewed. The clinical, laboratory and therapeutic data were compared between the two groups, Results Of 37 SLE patients with TB, 13 patients had pulmonary TB, 7 patients had pulmonary and extra-pulmonary TB, 17 patients had extra-pulmonary TB.Compared with the control group, SLE patients with TB were more likely to have received high mean daily dose of steroid or cytotoxic drugs, There was no difference bewteen the two groups in age, sex, duration of SLE,serum albumin/total protein level, and intravenous pulse methylprednisolone therapy, Conclusion There is a high prevelence of extra-pulmonary TB in SI,E patients, High mean daily dose steroid or cytotoxie drugs are important risk factors for the development of TB in SLE.
出处
《中华风湿病学杂志》
CAS
CSCD
2005年第8期476-479,共4页
Chinese Journal of Rheumatology
基金
上海市重点学科建设资助项目(T0203)
