摘要
目的设计合成2-(E)-(4-甲磺酰基)亚苄基环戊酮Mannich碱类化合物,并对其抗炎活性进行初步评价。方法以环戊酮、4-甲磺酰基苯甲醛及胺类化合物为原料,经多步反应合成目标化合物,并以二甲苯致小鼠耳肿胀模型测试目标化合物的抗炎活性。结果与结论共合成10个新化合物,经1H-NMR和MS确证其结构。初步药理实验结果显示9个目标化合物均具有一定的抗炎活性。
Aim The Mannich bases of 2- （ E ）- （4-methanesulfonyl） benzylidene cyclopentanone were designed and synthesized for studying their anti-inflammatory activities. Methods The target compounds were synthesized from cyclopentanone, 4-methanesulfonylbenzaldehyde and amines and their anti-inflammatory activity were evaluated with the model of xylene-induced ear edema in mice. Results and conclusion Ten new compounds are obtained and their structures are identified by MS and ^1H-NMR spectra. Preliminary pharmacological tests show that nine compounds exert anti-inflammatory activities.
出处
《中国药物化学杂志》
CAS
CSCD
2005年第4期193-196,i0001,共5页
Chinese Journal of Medicinal Chemistry
基金
辽宁省自然科学基金项目(20032044)
教育部高等学校博士学科点专项科研基金项目(20040163001)
