摘要
目的探讨胆囊原发性恶性黑色素瘤的临床病理特征、组织发生及鉴别诊断。方法对1例原发于胆囊的恶性黑色素瘤进行光镜观察,并行组织化学及免疫组化染色标记。结果组织学特征为:在上皮和固有层交界处黑色素肿瘤细胞呈巢状或片状分布,肿瘤细胞大小不等,形态多样。瘤细胞内外可见粗大的黑色素颗粒,MassonFontana染色阳性,免疫表型HMB45、vimentin及S100蛋白肿瘤细胞呈阳性表达。结论胆囊原发性恶性黑色素瘤罕见,诊断必须结合病史、全身检查及随访资料,以排除转移性恶性黑色素瘤。
Purpose To study the clinicopathological feature and histogenesis of primary melanoma of the gallbladder and its differential diagnosis. Methods A case of primary malignant melanoma arising from the gallbladder was studied histopathologcally with HE staining, histochemical and immunohistochemical techniques. Results The histological characteristics of the tumor were that the sheets and nests of melanoma cells were showed at the junction of the epithelium and lamina propria. The tumor cells varied in size and shape . Some thick melanin grains that stained as melanin pigment with Fontana-Masson were seen in or out of the cells. Immunohistochemical stains of HMB45, vimentin and S-100 protein were positive in the tumor cells. Conclusions Primary malignant melanoma of the gallbladder is extremely rare. It is difficult to distinguish primary from mestastatic lesions based on the histopathology alone. Diagnosis of primary melanoma can be made with combination of patient＇ s history, through physic examination and follow-up data after mestastatic lesions are excluded.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2005年第4期465-468,共4页
Chinese Journal of Clinical and Experimental Pathology
关键词
胆囊肿瘤
恶性黑色素瘤
免疫组织化学
诊断
鉴别
gallbladder neoplasms
malignant melanoma
immunohistochemistry
diagnosis, differential
