摘要
目的观察血管内皮生长因子(VEGF)在骨巨细胞瘤(GCT)中的表达和测定GCT肿瘤组织的微血管密度(MVD)。方法对34例骨巨细胞瘤患者的病理及临床资料进行回顾性研究。应用免疫组织化学方法检测肿瘤组织中VEGF的表达和MVD,并将上述两种研究资料与Jeffe分级和外科分期以及患者预后等临床资料进行统计学分析。结果VEGF及CD34在34例GCT中均有表达,GCT中VEGF的表达强度与MVD相关(P=0·044),且呈正相关(r=0·347);GCT的外科分期与VEGF的表达强度(P=0·001)和MVD(P=0·003)显著相关;GCT术后复发与VEGF的表达强度(P=0·034)和MVD(P=0·027)相关;而病理分级(Jeffe分级)与VEGF的表达强度和MVD之间差异均无显著性(P>0·05)。结论VEGF、MVD均与GCT外科分期及术后复发有关,而与病理分级无关。VEGF的高表达和高MVD预示GCT预后不良,其可能作为评价GCT预后的参考指标。
Objective To observe the expression of vascular endothelial growth factor （VEGF） in giant cell tumor of bone （GCT） and measure the microvessel density （MVD） in tumor tissue. Methods 34 cases of GCT were enrolled, and the pathology and clinic data were analysed respectively. The VEGF expression and MVD were assessed with immunohistological method and the data were performed statistical analysis with the pathology and clinic data. Results VEGF expression was found in all 34 cases, and the amount of VEGF expression correlated with MVD in GCT （ P = 0. 044 ）, and there was a positive correlation between them （ r = 0. 347 ）. The surgical staging of GCT significantly correlated with the amount of VEGF expression（P =0. 001 ） and MVD （P =0. 003）. The postoperative recurrence rate of GCT correlated with the amount of VEGF expression （P = 0. 034） and MVD （P = 0. 027）. The pathology pathology grading （Jeffe grading） was not related to the amount of VEGF expression and MVD （P 〉 0. 05 ）. Conclusion VEGF expression and MVD are correlated to surgical staging of GCT and the postoperative recurrence rate of GCT, not to pathology grading. Poor prognosis is indicated by high expression of VEGF and high MVD, which may be the indicators of GCT prognosis.
出处
《安徽医科大学学报》
CAS
北大核心
2005年第4期308-310,共3页
Acta Universitatis Medicinalis Anhui
关键词
血管内皮生长因子类
巨细胞瘤
骨/血液供给
免疫组织化学
vascular endothelial growth factor
giant cell tumor of bone/blood supply
immunohistochemistry
