摘要
目的:探讨肝硬化病人血清sIL-2R与ⅣC、LN、HA的变化,探讨慢性乙型肝炎患者sIL-2R水平与肝脏病理炎症和纤维化程度的关系。方法:100例按炎症和纤维化程度分组,32例对照,检测血中sIL-2R、ⅣC、LN和HA的含量,采用放射免疫分析。结果:sIL-2R、ⅣC、LN和HA的水平明显高于对照组(P<0.05～0.01);并随肝纤维化的进展而增高;sIL-2R水平随着肝组织炎症程度加重而加大;sIL-2R与ALT、AST、γ-GT、ALP呈显著正相关(r=0.5681;r=0.5784;r=0.5711;r=0.5841;P均<0.05)。结论:sIL-2R的变化可作为肝纤维化或肝硬化诊断的参考指标之一。
Objective To study the relationship between the serum sIL -2R levels and degree of hepatic fibrosis in liver biopsy specimens in patients with chronic hepatitis B. Methods Serum sIL- 2R, Ⅳ C, LN and HA contents （with RIA）, ALT, AST, γ- GT and ALP levels （with biochemistry） were determined in 100 patients and 32 controls. Liver biopsy specimens from the patients were examined for degree of fibrosis and inflammation. Results The serum sIL -2R, ⅣC, LN and HA levels in the patients were significantly higher than those in controls （P 〈0.05 ～0.01 ） , the values increased gradually along with progression of degree of hepatic fibrosis. Moreover, the sIL -2R levels also increased with the progression of severity of hepatitis. Levels of sIL -2R were significantly positively correlated with those of ALT, AST, γ-GT and ALP （r =0.5684,0.5784,0.5711,0.584;all P〈0.05）. Conclusion Serum sIL-2R is a useful marker of hepatic fibrosis.
出处
《放射免疫学杂志》
CAS
2005年第4期250-251,共2页
Journal of Radioimmanology
